• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    tool to collect animal tissue sample. the invention relates to a tool for collecting a sample of animal tissue, for interacting with collection means including at least one cutting element capable of cutting said sample and an impeller element which is mobile with respect to said cutting element, capable of of pushing said sample into storage media after cutting. according to the invention, such a tool includes: means for driving said cutting element (21), means for driving said driving element (23), and means for reversibly coupling said driving means of the cutting element with said means of driving the pusher element.
    公开号:BR112012031043B1
    申请号:R112012031043-7
    申请日:2011-06-09
    公开日:2020-05-26
    发明作者:Jean Jacques Destoumieux；Bruno Teychene
    申请人:Allflex Europe；
    IPC主号:
    专利说明:

    “TOOL TO COLLECT ANIMAL TISSUE SAMPLE”
    Field of invention
    [001] The field of the invention is that of the control and / or identification of animals.
    [002] More specifically, the invention belongs to the collection of tissue from an animal, made it possible especially to preserve cells carrying biological and biochemical characteristics of the animal, for example, in order to subsequently identify the animal and detect diseases in the animal.
    [003] More specifically, the invention belongs to the tool used to make such a collection.
    [004] The invention allows tissue samples from cows, sheep, pigs, goats, birds, fish or more in general any animal species to be collected with or without the simultaneous placement of an identification tag.
    Prior art
    [005] In order to improve livestock tracking, improve productivity (by eliminating sick animals or looking for unique genetic characteristics, for example) and guaranteeing the origin of animals intended especially for consumption (for example, detecting disease), it is becoming a frequent practice to collect one or more tissue samples from affected animals.
    [006] Such sampling can be done directly on the animal by placing a tag to identify the animal (at birth, for example) or later. Other sampling operations can be done throughout the animal's life, for example, to detect disease or certify the animal's identity, for example, by comparing DNA sequences. Once collected, the animal tissue sample can therefore be stored and / or transmitted to a laboratory for analysis.
    [007] Collection techniques currently used allow a tissue sample to be taken from the animal by placing an identification tag that can be visual or electronic.
    [008] Unfortunately, these sampling techniques require an adaptation of the existing labels, in structure and in the materials used. These restrictions can give rise to problems with the behavior of labels such as poor quality of life or premature aging.
    [009] Tissue collection techniques implemented independently
    Petition 870190126037, of 11/29/2019, p. 10/37
    2/24 of placing an identification tag is so well known.
    [010] As illustrated in figure 1, these techniques, for example, rely on the use of a perforator forming or comprising a cutting element 10 designed to cut a sample 11 of animal tissue and collect it in a housing. For this purpose, the cutting element 10 has a generally circular cutting edge which operates by continuous contact or is serrated.
    [011] The perforator 10, attached to a first jaw of a tool for collection, a clamp for example, cuts the animal's skin and is inserted at least partially into microtube 12 attached to a second jaw of the tool, while the tool is working . Punch 10 classically has a slightly smaller diameter than that of microtube 12 in order to serve as a plug for the microtube. The housing that receives sample 11, therefore, is open to the inside of the microtube, but closed to the outside of the microtube in order to prevent any contamination of the sample.
    [012] Through these collection techniques, sample 11 is directly inserted into microtube 12 thus limiting the risk of contamination of the sample.
    [013] Unfortunately, a drawback of this technique is that the animal's hair often remains trapped between the walls of the microtube and the perforator serving as a plug, giving rise to a receptacle impermeability problem. The preservation of the sample is therefore not guaranteed.
    [014] Furthermore, once the operator is inserted into the microtube, it is no longer possible to add any product to the microtube such as a preservative or reagent without having to remove or cut out the perforator.
    [015] Yet another drawback of this technique is that the perforator has to be manipulated in order to extract the tissue sample collected in the housing, and this operation could prove to be difficult and / or complicated, and present a risk of inflicting cuts on the user.
    [016] There is therefore a need for a new technique to collect tissue from an animal that does not have all these drawbacks of the previous technique.
    Summary of the invention
    [017] The invention proposes a new solution that does not have all these drawbacks of the prior art in the form of a tool for collecting a sample of animal tissue, intended to cooperate with collection means comprising at least one cutting element designed to cut the sample and an element im
    Petition 870190126037, of 11/29/2019, p. 11/37
    3/24 pulley that is mobile with respect to the cutting element, designed to push the sample into storage medium after cutting.
    [018] According to the invention, such a tool comprises:
    - means for driving the cutting element, allowing the cutting element to be moved along a translation axis in the direction of the fabric,
    - means for driving the pusher element making it possible to move the pusher element along the translation axis towards the fabric until the pusher element is at least partially inserted into the storage means,
    - means for reversibly coupling the means for driving the cutting element and the means for driving the driving element, these coupling means being movable between two positions:
    a coupling position that allows the movements of the cutting elements and impeller to be associated, and a decoupling position that allows the movements of the cutting elements and impeller to be dissociated.
    [019] The invention thus proposes a new tool to collect animal tissue, allowing the simultaneous action of the means to activate the cutting element and the means to activate the impelling element in a first stage and then only the means to activate the impelling element in a second stage, through only one action on the tool.
    [020] In other words, operations to cut tissue, extract tissue and close the tube are done in just one action, that is, only one movement for the user (the actuation of a lever, the triggering of a trigger, etc.) .
    [021] The proposed tool can be seen as a double pin (or double shank) mechanism, with a primary pin (or shank) transmitting the translation movement to the cutting element in order to cut the tissue sample and a pin secondary (or stem) transmitting the translation movement to the impelling element along the same direction to extract the cut tissue, these two pins being joined until the tissue is cut, and then being disconnected. The trajectory of the cutting element and the driving element through the animal tissue (the ear for example) is therefore straight.
    [022] The invention thus allows an optimized collection, particularly simple and fast for the user, who does not have to perform several actions to drill the
    Petition 870190126037, of 11/29/2019, p. 12/37
    4/24 animal tissue, pushing the sample into the storage media, closing the storage media etc., all of these operations being done through a single action on the tool (for example, a manual, electrical, pneumatic action or other action on the handles tool).
    [023] Furthermore, potential contamination of the sample is avoided as long as the user does not have to act directly on the sample. In addition, as the sample is cut out by the cutting element and then automatically pushed into the storage media by the pusher element, no part of the tool or any external element is in direct contact with the collected tissue.
    [024] According to a particular feature of the invention, the tool for collecting comprises at least one articulated handle forming a lever which is movable in a predetermined course comprising a first part and a second part.
    [025] A lever of this type comprises means of action on the coupling means allowing the passage from the coupling position in the first part to the uncoupling position in the second part.
    [026] Thus, when the user exerts pressure on the lever, it passes:
    - from an initial position to an intermediate position corresponding to a first part of the lever stroke during which the means for driving the cutting element and the means for driving the driving element are coupled; So
    - from the intermediate position to a final position, corresponding to a second part of the lever displacement, during which the means for driving the cutting element and the means for driving the driving element are uncoupled.
    [027] According to a first embodiment, the coupling means implement at least one mobile coupling element intended to cooperate with the housing made for this purpose in the means for driving the cutting element, the coupling element or elements being maintained in the coupling position and being released in the uncoupling position.
    [028] It can be noted that several coupling elements can be planned (for example, one, two, or three elements).
    [029] This first modality makes it possible to end the use of pre-tensioned springs designed to be compressed with a certain force.
    Petition 870190126037, of 11/29/2019, p. 13/37
    5/24
    [030] Thus, in the decoupling position, it is not necessary to accumulate the cutting forces and the forces used to close the storage media.
    [031] Furthermore, according to this first modality, the coupling means release the means for driving the cutting element from the means for driving the driving element according to the stroke of the lever and not the different forces involved: the force resistive to pass through the animal tissue (which differs according to the area in which the collection is made (due to a variation in the thickness of the tissue in particular) depending on the breed or category of the animal, the orientation of the tool with respect to the tissue a be collected, etc.), a force to close the storage media, a force exerted on the lever, etc. This allows for an improved repetition of the operation as the lever travel is always identical while the force exerted on the lever can be variable.
    [032] In particular, according to this first embodiment, the means for driving the pusher element comprise at least one groove and the housing faces the groove in the coupling position.
    [033] In this way, in the coupling position, the groove also receives the coupling element provided in the corresponding housing.
    [034] For example, the coupling element is a sphere, a cylinder, etc.
    [035] According to a particular aspect, the housing is a direct opening and the ball is held in the housing by means of a sliding part shaped to define retaining means retaining the ball in the groove in the coupling position and release means releasing the groove ball in the uncoupled position.
    [036] For example, the sliding part has a shape generated by the revolution around the translation axis defining a sleeve that comprises at least two sections of different diameters, and retention means corresponding to the section of smaller diameter and the release means with the larger diameter section.
    [037] The sliding part can be connected to the means for driving the driving element by a spring, called a sliding spring, the sliding spring tending to move the sliding part away from the means for driving the driving element. For example, the sliding spring is in an inactive state in the coupling position and in a compressed state in the uncoupling position.
    [038] According to a second modality, the coupling means
    Petition 870190126037, of 11/29/2019, p. 14/37
    6/24 implement a system known as a “disassembly” system.
    [039] More specifically, the coupling means implement a coupling spring positioned between the means for driving the cutting element and the means for driving the driving element, said coupling spring being pre-tensioned in order to require the application of a force greater than the force required to cut the sample to be compressed.
    [040] The pre-tensioned coupling spring thus fulfills the function of coupling the driving means of the driving element and means for driving the cutting element as far as the fabric is not cut, and then allows the movement of the driving element independently of the cutting element when the fabric cutting force is exceeded.
    [041] The solution according to this second modality is particularly simple to implement as it only requires the addition of a pre-tensioned spring.
    [042] According to this third embodiment, the coupling means implement a fitting system with at least one element at least partially deformable.
    [043] For example, such an element comprises several tongues or spring bundles extending substantially parallel to the translation axis, the tongues having at least one projection capable of cooperating with the complementary housing planned in the means for driving the cutting element in position coupling.
    [044] According to this third modality, the means for driving the cutting element therefore have a specific shape allowing them to be reversibly coupled with this at least partially deformable element.
    [045] Again, this third modality makes it possible to end the use of pre-tensioned springs, which are compressed in and beyond the application of a certain force. In the uncoupling position, therefore, it is not necessary to accumulate the cutting forces and forces to close the storage media.
    [046] Furthermore, as in the case of the first modality, the coupling means loosen the means to drive the cutting element of the means to drive the driving element depending on the stroke of the lever, and not of different forces involved according to this third mode, thus allowing a greater ability to repeat the operation.
    Petition 870190126037, of 11/29/2019, p. 15/37
    7/24
    [047] According to another feature of the invention, the collection tool comprises means for locking the storage means on an arm of the tool.
    [048] For example, these locking means are of a type of locking ring, translation element or other type.
    [049] They allow the storage medium, for example, a sampling tube, to be held firmly during the collection operation. Once the collection is made, the user can simply unlock these means to access the tube containing the sample. In this way, the user does not have to manipulate the sample directly.
    [050] According to another characteristic, the collection tool comprises means for ejecting the cutting element.
    [051] For example, after the fabrics are cut, the used cutting element is placed in an initial position and ejects the tool by a deliberate action on the part of the user, such as a lever action in reverse, for example , without direct contact with the user, in order to throw the cutting element in an appropriate area (a trash can, a recycling bin, etc.).
    [052] In this way, the user does not have to manipulate the dirty cutting element, thus preventing the risk of injury and contamination.
    [053] The collection tool is therefore designed so that at no time is the user in direct contact with the dirty cutting element and the collected sample.
    [054] According to another modality of the tool for collection, the means for driving the cutting element comprise a main piston and the means for driving the driving element comprise a secondary piston, the secondary piston being inertially moved to the uncoupling position .
    [055] According to this modality, a simple push by the user on a button or a trigger activates the instantaneous displacement of the main and secondary pistons in a first stage, and then only that of the secondary piston in a second stage, by inertia, after of a sudden stop of movement of the main piston.
    [056] In particular, according to this embodiment, the coupling means include a locking pin cooperating with a slot provided in the main piston, the locking pin being locked in the uncoupling position.
    Petition 870190126037, of 11/29/2019, p. 16/37
    8/24
    [057] Thus, the sudden stop of movement of the main piston can be caused by the blocking of the locking pin, causing the coupling means to move from the coupled position to the uncoupled position.
    [058] According to a particular aspect of the invention, the collection tool comprises means for the automatic removal of the cutting element.
    [059] Such means allow the animal's ear to be released quickly, and avoid the risk of the user or the animal being cut with the dirty cutting element, protecting the cutting edge of the cutting element.
    List of Figures
    [060] Other aspects and advantages of the invention will appear more clearly from the following description of a particular modality, given by means of a simple, illustrative and non-exhaustive example and from the attached drawings, of which:
    Figure 1 illustrates a device for collecting a tissue sample according to the prior art;
    Figures 2 and 3 respectively show a sectional view of the collection means and the storage means that can be implemented by a collection tool according to an embodiment of the invention;
    - Figure 4 illustrates a tool for collection according to an embodiment of the invention in an initial position;
    - Figures 5A and 5B provide a more accurate illustration of the different elements of the collection tool, according to Figure 4, during collection;
    Figures 6 and 7 show an example of a mechanism for ejecting the cutting element from the collection tools in Figure 4;
    - Figures 8A and 8B respectively illustrate the collection tool of Figure 4 and the storage means after the collection operation;
    Figures 9A and 9B propose a first example of an embodiment of the coupling means according to the invention;
    Figure 10 shows a second example of an embodiment of the coupling means according to the invention;
    Figures 11A and 11B illustrate a third example of an embodiment of the coupling means according to the invention;
    Figures 12A to 12H illustrate another example of implementing the invention;
    Petition 870190126037, of 11/29/2019, p. 17/37
    9/24
    - Figures 13A to 15 show different techniques that allow an automatic removal of the cutting element after cutting the fabrics.
    Description of an embodiment of the invention
    General Principle
    [061] The general principle of the invention relies on the operation of a specific collection tool in two stages, allowing the use of collection means comprising a cutting element and an impelling element to collect an animal tissue sample as described, for example, in the patent application filed under number FR-08 58453.
    [062] More specifically, a collection tool of this type allows a simultaneous movement of the cutting element and the driving element in a first stage and then the movement of the driving element only in a second stage.
    [063] The tool according to the invention comprises means for driving the cutting element and means for driving the driving element, allowing the cutting element and the driving element to be moved to the fabric to be collected, and means for coupling reversible means for driving the cutting element and means for driving the pusher element.
    [064] These coupling means allow two positions to be defined:
    - a coupling position allowing the movement of the cutting element and driving element to be connected and, therefore, allowing these two elements to be moved simultaneously, and
    - an uncoupling position allowing the movements of the cutting element and the driving element to be dissociated and, therefore, allowing the driving element to be moved separately.
    Description of a Particular Modality
    [065] Here below, a particular modality is described in which the collection tool according to the invention is used to make a collection using the means for collection and storage as described in French patent application FR-08 58453.
    A) Means for Collection
    [066] Here below, we recall the main characteristics for collection described in the French Patent application FR-08 58453.
    Petition 870190126037, of 11/29/2019, p. 18/37
    10/24
    [067] As shown in Figure 2m, these collection means comprise first a cutting element 21 and secondly an impelling element 23. The cutting element 21 can especially be fixedly attached to a support 22. This support that can be made of plastic, it is intended to be detachably mounted on the end of a rod fixedly attached to one of the arms of a collection tool. It takes the form of a surface generated by the revolution having the same axis as the cutting element 21 and the driving element 23. It comprises especially a flange 221 on which it is possible to fix the shank to drive the cutting element.
    [068] According to a variant, the cutting element 21 and the support 22 are formed as an integral part, for example made of plastic or metal. The cutting element 21 and the support 22 are considered here to form a single piece, which is a “monoblock” unit.
    [069] The cutting element 21 is considered, for example, to have a shape generated by the cylindrical revolution. The cutting edge 211 then has a circular shape.
    [070] The cylinder that forms the cutting element 21 is open at both ends in order to let the impeller element 23 pass through so that the latter can push the sample out of the cutting element 21 and accompany it into the storage medium along the direction illustrated by arrow F.
    [071] According to the exemplary embodiment illustrated, the pusher element 23 also has a cylindrical shape generated by revolution. However, the diameter of the driving element 23 must be smaller than that of the cutting element 21 so that the driving element 23 can slide into the cylinder formed by the cutting element 21.
    [072] The driving element 23 is movable in translation along the axis A-A within the cutting element 21 along the direction illustrated by the arrow F.
    B) Storage media
    [073] We also recall the main characteristics of the storage media described in the French patent application FR-08 58453.
    [074] As illustrated in figure 3, these storage means comprise first a sampling tube 31 comprising at least one opening and secondly a tube top 32 fixedly attached to the inlet of the sampling tube, for example, being attached or being docked. It can be done
    Petition 870190126037, of 11/29/2019, p. 19/37
    11/24 a flexible material, for example rubber, to facilitate its insertion in the neck of the tube.
    [075] More specifically, the tube top 32 takes the form of a perforated cover with a central opening having a diameter sufficient to allow the insertion of at least part of the pusher element 23. The use of a flexible material for this cover also facilitates the insertion of the pusher element 23 into the tube 31. The pusher element 23 then closes the tube 31 in an impermeable or almost impermeable manner.
    [076] The tube top 32 also has a flange resting on the rim of the sampling tube 31, defining a stop surface (or block) on which the cutting edge of the cutting element 21 can be supported during the collection operation a to cut the tissue sample more easily.
    C) Collection Tool
    [077] Here below, several examples of the collection tool are described, sometimes also called an applicator or tweezers, which can be used to collect a sample of tissue according to the invention.
    i) General operation As illustrated in Figure 4, a tool of this type in general has a fixed part also called a body 41 defining especially a pine and an articulated part also called a lever 42 defining a second handle.
    [078] The body 41 of the tool also defines two arms between which the tissue to be collected, for example, the ear of the animal 43, is positioned. Thus, the first arm 411 is designed to cooperate with collection means as illustrated in Figure 2, for example, and the second arm 412 is designed to cooperate with storage means as illustrated in Figure 3, for example.
    [079] More specifically, the second arm 412 comprises means for locking the sampling tube such as a locking ring, for example.
    [080] The first arm 411 for its part comprises means 44 for driving the collection means, allowing the cutting element 21 (and / or its support 22) and the pusher element 23 to be moved in translation to the fabric to be collected , along the translation axis AA. These actuating means are activated when the user of the tool exerts a force on the lever 42.
    [081] Thus, lever 42, which can be actuated manually, for example
    Petition 870190126037, of 11/29/2019, p. 20/37
    12/24 plo, acts on the drive means 44 in order to guide the collection means in a translation movement so that they penetrate the meat of the animal and force the sample collected in the storage means. The tool can also be operated using electric, pneumatic or other energy. The means of collection and storage are therefore configured to cooperate with such a tool.
    [082] More specifically, the driving means 44 includes means for driving the cutting element 21 (and / or its support 22), means for driving the driving element 23, and means for inversely coupling these driving means. Thus, in its first stage, corresponding to a first part of the stroke of the lever 42 between an initial position and an intermediate position, the means for driving the cutting element 21 and the means for driving the driving element 23 are coupled in a position of coupling that allows the movements of the cutting element and the driving element to be joined. In a second stage, corresponding to a second part of the stroke of the lever 42 between the intermediate position and an end position, the means for driving the cutting element 21 and the means for driving the driving element 23 are decoupled in an uncoupling position allowing the movements of the cutting elements and impeller are dissociated.
    [083] Figure 4 illustrates the initial state of the applicator when the collection and storage means are mounted on the tool that is ready for use.
    [084] Figures 5A and 5B provide a more accurate illustration of the different elements of the tool to collect during collection and especially the two positions, namely the coupling and uncoupling positions. The cutting element 21 is considered, for example, to be guided in translation by the driving means 441 and the driving element 23 is considered, for example, to be guided in translation by the driving means 442 by pushing the driving element 23 through the driving element cut 21.
    [085] As illustrated in Figure 5A, the driving means 441 of the cutting element and the driving means 442 of the driving element are connected in a coupling position in a first stage corresponding to the first part of the lever stroke 42. A action on lever 42 between its initial position and its intermediate position which corresponds to the first part of its course then gives rise to the simultaneous translation of the cutting element 21 (or its su
    Petition 870190126037, of 11/29/2019, p. 21/37
    13/24 port 22) and the pusher element 23 along the same translation axis.
    [086] This translation allows the cutting element to pierce the ear 43 in a straight path to cut a tissue sample until it contacts the flange of the tube top part of the sampling tube 31.
    [087] In a second stage, corresponding to a second part of the stroke of the lever 42, as illustrated in Figure 5B, the driving means 441 of the cutting element and the driving means 442 of the driving element are no longer joined. Thus, in this uncoupling position, the continuation of the action on lever 42 in this second part gives rise to a translation of the driving element 23, alone. The pusher element 23 is then guided in translation through the cutter element 21 (locked in a contact position against the flange of the tube top part) and pushes the cutout sample 431 to the tube 31. The pusher element 23 ends its stroke being fitted to the tube top piece and thus blocks the tube 31 hermetically or almost hermetically.
    [088] In other words, the action of the pusher element begins after the cutting element has tissue cut against an “anvil” (the flange of the tube top part of the sampling tube 31) thus ensuring a clean and repeated cut of the first by, cartilage, and second skin.
    [089] With the sample collection having been done in a safe manner, the user can then release lever 42. A return spring 45 or any other means can then place the lever in its initial position as well as placing the actuation means 441 of the cutting element and the driving means 442 of the driving element back to its initial position, i.e. to its coupling position.
    [090] The cutting element can thus be placed in the home position. In this way, the cutting element remains neither in the storage media nor in the animal and can assume any shape particularly well suited to cut the animal tissue, and especially the shape of an extremely sharp edge.
    [091] In accordance with a particular aspect of the invention illustrated in Figure 6, the collection tool provides a means for ejecting the cutting element 21 after use. For example, the user can apply a reverse rotation (or translation) movement on lever 42, tending to move the first handle 41 away in ten from approaching it (arrow B). This movement of reverse rotation (or translation) gives rise to a translation of the means 441 to drive the cutting element and the half
    Petition 870190126037, of 11/29/2019, p. 22/37
    14/24 os 442 to drive the pusher element in an F -1 direction, opposite the collecting direction F. Means 441 for driving the cutting element then drives the cutting element 21 in the F -1 direction, until the flange 221 of the cutting element holder 22 contacts the means planned for this purpose in the tool body. This support 22 and the cutting element 21 are then disconnected from the driving means 441 and ejected from the tool for collection without the user having to touch the dirty cutting element.
    [092] The user can thus eject the dirty cutting element, when he wishes, in an appropriate place, without having to touch this element, thus preventing the risks of cutting or contamination.
    [093] Before ejection, the user can of course place a protective element on the cutting element 21.
    [094] According to this aspect, stopping the lever in the initial position (or idle position) is considered to be elastic. It can be done by a damping system or a spring 46, as illustrated in Figure 7, placing the lever 42 and the entire mechanism in the initial position. The movement of the lever 42 relative to the body 41 in the opposite direction to the collection direction is therefore permitted.
    [095] Finally, the user can unlock the locking means 81 of the tube 31, for example, by turning a locking ring, or translating a locking element, in order to recover the sample 431 stored in the tube 31 as illustrated in Figure 8A . As illustrated in Figure 8B, sample 431 is then ready to be transmitted to a laboratory in its sampling tube 31 capped by the pusher element 23.
    ii) First example of a coupling means modality
    [096] Here below, a first example of an embodiment of the coupling means is described which allows a coupling position of the means 411 to move the cutting element and the drive means 442 to the uncoupling position.
    [097] According to this first example, the coupling means implement at least one mobile coupling capable of operating with a housing made for this purpose in the means 441 to drive the cutting element. These coupling means (balls, cylinders or the like) are held in the housing in the coupling position and released in the uncoupling position.
    [098] More specifically, Figures 9A and 9B illustrate means 441 and
    Petition 870190126037, of 11/29/2019, p. 23/37
    15/24
    442 to drive the cutting element and the driving element corresponding to the positions illustrated in Figures 5A and 5B respectively.
    [099] According to this first example, the means 441 for driving the cutting element is considered to comprise one or more housings 91 each receiving a ball 92. The means 442 for driving the driving element for its part comprises at least one groove 93 such that each housing 91 faces slot groove 93 in the coupling position.
    [0100] In the coupling position shown in Figure 9A, housing 91 is a direct opening (hole) and ball 92 is held in housing 91 by means of a sliding part 94. In the uncoupling position shown in Figure 9B, the ball 92 is no longer maintained by means of the sliding part 94.
    [0101] For example, a sliding part 94 of this type has a shape generated by revolution around the translation axis that defines a sleeve comprising at least two sections of different diameters. The smaller diameter section 941 allows ball 92 to be kept in groove 93 in the coupling position. The larger diameter section 942 allows ball 92 to be released from groove 93 in the uncoupled position.
    [0102] The sliding part 94 is connected to the means 442 to drive the impelling element by a spring, called a sliding spring 95, proposed according to this example in a state of rest in the coupling position and in a state of compression in the position decoupling.
    [0103] More specifically, during collection, means 441 for driving the cutting element and means 442 for driving the pusher element are coupled in a first stage as shown in Figure 9A, thus causing a simultaneous translation of a cutting element and the driving element.
    [0104] The cutting element then pierces the animal's ear to cut out a tissue sample. Just before the cutting element contacts the flange of the tube top part of the sampling tube, the sliding part 94 is also in contact with a stop element (such as a shoulder) provided for this purpose in the tool body, in its section 942 with a larger diameter. As the user continues his action on the lever 42 while the sliding part 94 is in a counter-support, the means 442 to drive the impeller element continue to push the impeller element 23 and guide the sphere or spheres 92 that were held by the section 941 with the smaller diameter of the sliding part 94 for section 942
    Petition 870190126037, of 11/29/2019, p. 24/37
    16/24 with the largest diameter. The balls 92 are then released and the means 441 for driving the cutting element and the means 442 for driving the driving element are decoupled, as shown in Figure 9B, and the driving element can continue its movement independently of the cutting element.
    [0105] When the spheres are released, the cutting element contacts the flange of the tube top part of the sampling tube.
    [0106] It can be noted that the primary spring 96 provided between the means 441 to drive the cutting element and the means 442 to drive the driving element makes it possible to keep the cutting element under pressure against the flange of the pipe top part of the sampling tube, especially when the sliding spring 95 is compressed.
    iii) Second example of a modality of the coupling means
    [0107] Here below, a second example of a modality of the coupling means is described implementing a "remover" type system.
    [0108] According to this example, illustrated in Figure 10, a coupling spring 101 is provided, positioned between the means 441 to drive the cutting element and the means 442 to drive the driving element.
    [0109] More specifically, a coupling spring such as this is pre-tensioned and designed to be compressed when a force is applied to it that the force required for the cutting element to cut the sample. It is thus ensured that the movements of the cutting element 21 and the driving element 23 are identical (means 441 for driving the driving element in a coupling position) insofar as it has not perforated the animal tissue.
    [0110] In fact, to the extent that the cutting element does not contact the flange of the tube top part of the sampling tube, the coupling spring 101 is not compressed because the force exerted if the user continues its action on lever 42 , the force exerted on the cutting element is sufficient to perforate the animal tissue but not sufficient to compress the coupling spring 101.
    [0111] Once the cutting element is in contact with the flange of the tube top part of the sampling tube, the coupling spring 101 is compressed if the user continues its action on lever 42, the force exerted on the cut then being larger than that needed to perforate the animal tissue.
    [0112] For example, if the force required for the cutting element to cut the sample is considered to be in the order of 60 Newton, the coupling spring
    Petition 870190126037, of 11/29/2019, p. 25/37
    17/24
    101 can be pre-tensioned at a force of about 80 to 100 N.
    iv) Third example of a coupling means modality
    [0113] Here below, a third example of an embodiment of the coupling means is described implementing a locking system with an at least partially deformable element.
    [0114] As shown in Figures 11A and 11B, the at least partially deformable element 111 comprises, for example, a base 112 designed to support the means 442 for driving the pusher element, assuming, for example, the shape of a rod. Several tongues, for example, three tongues 113, extend from this base 112, substantially in parallel with the translation axis of the cutting elements and impeller.
    [0115] Each tongue 113 comprises a projection or projection 114 capable of cooperating with a corresponding housing provided in means 441 to drive the cutting element in the coupling position.
    [0116] More specifically, the tongues 113 form spring bundles to maintain the means 441 for driving the cutting element in the coupling position.
    [0117] During the collection operation, means 441 for driving the cutting element and means 442 for driving the pusher element are coupled in a first stage, by means of the partially deformable element 111, as illustrated in Figure 11A, and this causes the simultaneous translation of the cutting element and the driving element.
    [0118] While the cutting element pierces the animal's ear and contacts the flange of the tube top part of the sampling tube, the means 442 for driving the pusher element continues to push the pusher element 23 and the partially deformable element 111. The user continuing his action on the lever 42, the spring tongues or bundles 113 then spread, disengaging the projections 114 of the complementary housings provided in the means 441 to drive the cutting element, thus releasing the means 441 to drive the cutting element. The means 441 for driving the cutting element and the means 442 for driving the driving element are then in the uncoupled position.
    [0119] According to a variant, specific deformation means can be designed in the tool body to deform the tongues 113 when the free end of these tongues contacts these deformation means.
    [0120] It can be noted that the primary spring 115, supplied between the means
    Petition 870190126037, of 11/29/2019, p. 26/37
    18/24
    441 for driving the cutting element and the means 442 for driving the pusher element allows pressure to be maintained on the cutting element against the flange of the tube top part of the sampling tube especially when the spring tongues or bundles 113 are deformed .
    v) Another modality
    [0121] Here below, referring to Figures 12A to 12H, another exemplary embodiment of the invention known as an "inertia-based" embodiment is presented.
    [0122] In this example, the means for driving the cutting element take the form of a main “piston” 121 and the means for driving the driving element take the form of a secondary “piston” 122. The main and secondary pistons can slide on the applicator body, for example, on a first arm, in a translation movement. The secondary piston can slide inside the main piston, also in a translation movement.
    [0123] The coupling means especially comprise a “locking pin” 123 held in position on the applicator body, cooperating with a slot 1231 provided in the main piston 121. A notch 1232 for releasing the locking pin is also provided in one of the slit ends 1231. When the main piston slides in the applicator body, the position of locking pin 123 in slit 1231 is modified. This corresponds with the coupling position of the main and secondary pistons. In particular, when the locking pin 123 faces the notch 1232, it is locked in position, thus releasing the movement of the secondary piston. This corresponds with the decoupling position of the main and secondary pistons.
    [0124] Figure 12A provides a more accurate illustration of the position of main piston 121 and secondary piston 122 at rest.
    [0125] Prior to the collection operation, the collection and storage means are mounted on the piston-based system. For this purpose, as illustrated in Figure 12B, the user can move the main piston forward along the direction of arrow A, and therefore the secondary piston, the movement of which is connected to the main piston through the coupling means in the position coupling. The collection means comprise the cutting element 21 (possibly fixedly attached to a support) and the pusher element 23 and can then be mounted on the main piston 121. The storage means 31 can be mounted on a second arm
    Petition 870190126037, of 11/29/2019, p. 27/37
    19/24 of the applicator. It can be noted that the means of collection and storage can be held together by means of a connecting piece. This assembly can be fixed on one of the applicator arms, for example, in the storage media, by a clamp assembly, a locking ring etc. An action by the user on the applicator allows the collection means to be fixedly attached to the other arm by a fitting or clamping effect. The connecting piece can, for example, remain in the collection means in order to protect the cutting element before collection.
    [0126] When the user is ready to perform the collection operation, he can remove or eject the connection piece and "prepare" the applicator by placing the piston-based system in a direction opposite the arrow A, as shown in Figure 12C. This operation can be done with a mechanism that increases the force in order to compress a spring 124 connected to the main piston 121 until a locking position is reached. Such a mechanism, for example, takes the form of a nut with an adapted thread, a lever system, a pump, a rack system, a jack-type electrical mechanism, a micromotor, etc. The compression of the spring 124 makes it possible to collect energy. During this step, as the coupling means are in a coupling position, the movements of the main and secondary pistons are always on.
    [0127] According to a variant not shown, the preparation operation can be performed by connecting the tool to an external power source (compressed air in a cartridge or in a network, for example).
    [0128] As shown in Figure 12D, the user can then position the animal's ear 43 between the two arms of the applicator, and then actuate an unlock button, which releases the compression exerted on spring 124. spring 124 relaxes, making the main piston 121 and secondary piston 122, which are still in the coupling position, move towards the animal's ear. This action on an unlocking button gives rise to greater acceleration allowing the cutting element to pierce the animal's ear. The energy required to move the main piston can thus be provided by compression / decompression of spring 124 instead of by the user.
    [0129] According to the variant mentioned above, the acceleration could be obtained by the pressure of the compressed air in the main piston, by means of a jack, for example.
    [0130] The main piston 121 and the secondary piston 122 continue their
    Petition 870190126037, of 11/29/2019, p. 28/37
    20/24 connected until the cutting element 21 pierces the ear of the animal 43 as illustrated in Figure 12E. The movement of the main piston 121 suddenly stops when the cutting element 21 contacts the collection means, especially the tube top 32 and / or when the locking pin 123 penetrates the notch 1232 provided for this purpose.
    [0131] This makes it possible to decouple the decoupling means and therefore to decouple the movements of the main and secondary pistons.
    [0132] In other words, as illustrated in Figure 12F, the sudden stop of movement of the main piston 121 when the cutting element 21 contacts the collection means and / or when the locking pin 123 penetrates the notch 1232 supplies the piston secondary 122, according to the law of conservation of amounts of movement giving rise to a translational displacement of the secondary piston 122, propelling the impeller element towards the animal's ear. The pusher element thus extracts the cut sample from the cutting element, pushes it into the collection tube and closes the sampling tube 31. In this mode, the secondary piston is therefore actuated only by inertia.
    [0133] The secondary piston can especially assume a specific shape as illustrated in the Figures, including an enlargement that pushes locking pin 123 back out of the notch 1232 to release the movement of the main piston. Thus, as illustrated in Figures 12G and 12H, the main piston and then the secondary piston can resume their initial position after releasing the main piston, for example, under the action of low stiffness return springs.
    [0134] As described with reference to the other modalities, it is possible for a user to eject the dirty cutting element, for example, by pulling on the main piston in a direction opposite arrow A, with a part of the cutting element support contacting an element provided for this purpose on the applicator body.
    [0135] The other features and advantages described here above with reference to the other modalities can also be applied in this modality and therefore are not repeated in detail here.
    D) Automatic removal of the cutting element
    [0136] According to a particular embodiment of the invention, the cutting element can automatically resume its initial position once the sample has been cut out. This automatic withdrawal frees the animal's ear and prevents the risk of cutting with a dirty cutting element, protecting the cutting edge of the animal.
    Petition 870190126037, of 11/29/2019, p. 29/37
    21/24 cutting length.
    [0137] For example, this automatic withdrawal can occur when the cutting element contacts a contact surface, such as the tube top part, or when a locking pin penetrates a notch for this purpose according to the modality described here above.
    [0138] In a first example as described above with reference to Figures 12F to 12H, the automatic removal of the cutting element can be obtained using a specific shape for the secondary piston, comprising an enlargement that allows the locking pin 123 to be pushed back out of notch 1232. This releases the movement of the main piston and takes it to the rest position (thus protecting the cutting edge) and puts the secondary piston back to the rest position under the return springs low rigidity.
    [0139] According to a second example, illustrated in Figures 13A and 13B, the automatic removal of the cutting element is implemented through the combined use of a return spring 131 connected to means 442 to drive the impeller element, a pin transmission 133 connected to the driving means 442 and an opening 132 in the body 41 of the applicator, in which the transmission pin 133 can move.
    [0140] As described here above with reference to Figures 5A and 5B, the actuation of lever 42 gives rise above all to a simultaneous translation of the cutting element 21 and the pusher element 23 allowing the cutting element to cut out a tissue sample until it contacts the flange of the tube top part of the sampling tube 31. Continuing this action on the lever 42 then causes a translation of the impeller element 23 only, through the cutting element 21, thus giving rise to a compression of the spring return 131 against the applicator body.
    [0141] The displacement of the means 442 for driving the impeller element also triggers a displacement of the transmission pin 133 along the opening 132. In this variant, the opening has an inclination. Thus, the drive pin 133 is maintained in a notch provided for this purpose in the drive means 442 in a first stage and then, as and when displacement occurs through the opening 132, the drive pin 133 is released from the means of drive 442. For example, the drive pin 133 is held in a support position against the inclination of the opening 132 by means of a spring 134 fixedly
    Petition 870190126037, of 11/29/2019, p. 30/37
    22/24 attached to lever 42.
    [0142] Once the drive pin 133 is released from the drive means 442, the return spring 131 relaxes and retracts the means 442 to drive the driving element and then means 441 to drive the cutting element (connected by a spring 135) in its initial position.
    [0143] According to a third example, illustrated in figure 14, the automatic removal of the cutting element is implemented through the combined use of a chain 141 formed by two links, at least one plate 142 and a cam 143 acting in the means 442 to drive the pusher element.
    [0144] More specifically, the actuation of lever 42 gives rise to a movement of the chain 141 transmitting the necessary force for the rotation of the plate 142. The rotation of the plate 142 acts on the cam 143 which, in turn, acts the means to actuate the driving element and the cutting element, simultaneously in a first stage and then dissociated in a second stage.
    [0145] At the end of the displacement of the lever 42, a stop 144 integrated in the body of the applicator forces the chain 141 to be curved. Then it can no longer transmit any force to the plate 142 which returns to its initial position under the effect of the return springs. Subsequently, cam 143 also returns to its starting position.
    [0146] Means 442 for driving the pusher element and means 441 for driving the cutting element also return to their initial position insofar as no more force is applied by the cam 143 to the driving means.
    [0147] Finally, Figure 15 illustrates a fourth example of the automatic removal of the cutting element, implementing a hook-based mechanism.
    [0148] In this example, the means 442 for driving the pusher element is provided with hooks 151 used to prepare the applicator and for automatic removal of the cutting element once the collection operation is finished.
    [0149] The preparation of the applicator is done, for example, by pushing the means 442 to activate the impeller element until the hooks 151 hook an element C that corresponds with the applicator, leading to the compression of a return spring 152 between the base and the means 442 for actuation and the hook element C.
    [0150] The displacement of the element with hook C and the means 442 to activate the propelling element, by the action of the applicator, for example, from the origin AnPetição 870190126037, of 11/29/2019, pg. 31/37
    23/24 everything to a translation of the cutting element 21 and the driving element 23 (the means 441 for driving the cutting element being connected to the means 442 for driving the driving element by means of a spring 153). When the cutting element contacts the flange of the tube top part of the sampling tube, the spring 153 is compressed and only the impeller element 23, pushed by the driving means 442, continues its course through the cutting element 21.
    [0151] Compression of the spring 153 places the hooked element C in contact with a corresponding “release” element D, allowing the hooks 151 to be released from the hooked element C. Once the hooks 151 of the drive means 442 they are unlocked, the return spring 152 relaxes and returns means 442 to drive the driving element and then means 441 to drive the cutting element (by means of spring 153) to its initial position.
    [0152] It should be noted that these four implementation examples are described in the case where the applicator works with collection means comprising a cutting element and an impeller element. These mechanisms could of course be implemented in a "classic" applicator that works with collection means comprising a simple perforator not combined with an impeller element.
    E) Variants
    [0153] Regardless of the modality considered, the collection tool according to the invention provides a translation movement to the cutting elements and impeller along the same direction, the two movements being associated in a first stage and dissociated in a second internship.
    [0154] It can be recalled that these two stages correspond to a single action by the user on the collection tool, the first stage corresponding to a first part of the lever travel between an initial position and an intermediate position, defining a coupling position, and the second stage corresponding to a second part of the lever travel between the intermediate position and an end position, defining an uncoupling position.
    [0155] Other coupling means can also be considered in that they allow a parallel double movement of translation of the cutting element and the driving element, simultaneously in a first stage and then in a posterior dissociated way, so that the cutting element cuts the tissues of the animal before the pusher element pushes the sample thus cut.
    [0156] In the described mode, the collection tool is operated manually
    Petition 870190126037, of 11/29/2019, p. 32/37
    24/24 mind. Naturally, it could be acted by means of electric, pneumatic or other forms of energy.
    [0157] Furthermore, in the described mode, the lever is movable in rotation between the initial, intermediate and final positions. In a variant, not shown, the lever can be moved in translation between these different positions.
    [0158] According to yet another modality, the collection tool can place an identification tag (visual and / or electronic) simultaneously with the sample collection. Advantageously, this identification mark carries an identifier linked to an identifier of the means of collection and / or storage.
    权利要求:
    Claims (10)
    [1]
    1. Tool for collecting a sample of animal tissue, intended to cooperate with collection means comprising at least one cutting element (21) designed to cut said sample and an impeller element (23) that is movable with respect to said element of cut (21), designed to push said sample into storage media after cutting, said storage means comprising a sampling tube (31) and a tube top (32), CHARACTERIZED by the fact that said tool comprises :
    - means (441) for driving said cutting element (21), allowing said cutting element (21) to be moved along a translation axis in the direction of said fabric,
    - means (442) for driving said pusher element (23), allowing said pusher element (23) to be moved along said translation axis towards said fabric until at least a part of said pusher element (23 ) is inserted into said tube top,
    - means for reversible coupling (91,92) of said means for driving the cutting element (21) and said means for driving the driving element (23), said coupling means being movable between two positions:
    a coupling position that allows the movements of the cutting elements (21) and impeller (23) to be associated, and a decoupling position that allows the movements of the cutting elements and impeller to be dissociated, said coupling means implementing by the at least one movable coupling element (92) intended to cooperate with a housing (91) designated for that purpose in said means for driving said cutting element (21), said coupling element or elements being maintained in said housing (91 ) in said coupling position and being released in said uncoupling position.
    [2]
    2. Tool to collect, according to claim 1, CHARACTERIZED by the fact that it comprises at least one articulated handle forming a lever (42) which is movable in a predetermined course comprising a first part and a second part, said lever ( 42) comprising means of action in said coupling means that allow the passage of said coupling position in said first
    Petition 870190126037, of 11/29/2019, p. 34/37
    2/3 the part for said decoupling position in said second part.
    [3]
    3. Tool for collecting, according to either of claims 1 or 2, CHARACTERIZED by the fact that said means for driving the impelling element (23) comprise at least one groove (93), said housing turns to said groove in said coupling position.
    [4]
    4. Tool to collect, according to any one of claims 1 to 3, CHARACTERIZED by the fact that said at least one coupling element is a sphere (92).
    [5]
    5. Tool to collect, according to claim 4, CHARACTERIZED by the fact that said housing is a direct opening and in which said sphere is maintained in said housing by means of a sliding part (94), said sliding part being formed to define retaining means retaining said sphere in said groove in said coupling position, and release means releasing said sphere from said groove in said uncoupling position.
    [6]
    6. Tool to collect, according to claim 5, CHARACTERIZED by the fact that said sliding part has a shape generated by the revolution around said axis of translation defining a glove that comprises at least two sections (941, 942) of different diameters, said retention means corresponding to the section (941) of smaller diameter and said release means corresponding to the section (942) of larger diameter.
    [7]
    7. Tool for collecting, according to either of claims 5 or 6, CHARACTERIZED by the fact that said sliding part is connected in said means to drive the impelling element (23) by a spring (95), called a sliding spring , said sliding spring being in an inactive state in said coupling position and in a compressed state in said uncoupling position.
    [8]
    8. Tool for collecting, according to any one of claims 1 to 7, CHARACTERIZED by the fact that it comprises means for locking said storage means in an arm of said tool.
    [9]
    9. Tool for collecting, according to any one of claims 1 to 8, CHARACTERIZED by the fact that it comprises means for ejecting said cutting element (21).
    Petition 870190126037, of 11/29/2019, p. 35/37
    3/3
    [10]
    10. Tool to collect, according to any one of claims 1 to 9, CHARACTERIZED by the fact that it comprises means for the automatic removal of said cutting element (21).
    类似技术:
    公开号 | 公开日 | 专利标题
    BR112012031043B1|2020-05-26|TOOL TO COLLECT ANIMAL TISSUE SAMPLE
    CA2744494C|2016-04-26|Device for collecting a tissue sample from an animal
    EP1832235B1|2009-09-09|Device for minimally invasive internal tissue removal
    US6106484A|2000-08-22|Reusable automated biopsy needle handle
    EP1839582B1|2009-03-11|Device for minimally invasive internal tissue removal
    US7806834B2|2010-10-05|Device for minimally invasive internal tissue removal
    WO1995010235A1|1995-04-20|Morcellator system
    US8486088B2|2013-07-16|Ear tag installation tool and method
    BR112015015894B1|2020-04-22|animal identification system that includes a male portion, a female portion and a removable device for storing a sample
    US10966692B2|2021-04-06|Quick release driving tool
    JPH0880310A|1996-03-26|Ovariectomy appliance for mammal
    WO2019030654A1|2019-02-14|Animal tag attachment tool
    CN106859800A|2017-06-20|A kind of tumor planting device
    同族专利:
    公开号 | 公开日
    US20130204159A1|2013-08-08|
    NZ604083A|2013-09-27|
    EP2579782A1|2013-04-17|
    PT2579782T|2018-12-11|
    AU2011263687B2|2015-02-26|
    CA2799027A1|2011-12-15|
    CA2799027C|2018-11-27|
    US9955954B2|2018-05-01|
    BR112012031043A2|2016-10-25|
    FR2961087B1|2013-06-28|
    EP2579782B1|2018-09-05|
    AU2011263687A1|2013-01-10|
    DK2579782T3|2019-01-07|
    CN102933157A|2013-02-13|
    WO2011154510A1|2011-12-15|
    FR2961087A1|2011-12-16|
    ES2701025T3|2019-02-20|
    CN102933157B|2015-04-15|
    CY1121526T1|2020-05-29|
    PL2579782T3|2019-04-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US42188A|1864-04-05|Closing ob stopping bottles |
    US1347868A|1919-06-06|1920-07-27|Samuel R Nichols|Animal-tag|
    FR858453A|1939-07-28|1940-11-26|Bendix Aviat Corp|Control devices|
    US2570048A|1946-05-03|1951-10-02|Aviat Developments Ltd|Tool for marking animals' ears for identification|
    US2617359A|1951-11-16|1952-11-11|George E Van Horn|Hypodermic projectile|
    US2749566A|1952-09-04|1956-06-12|Bristol Myers Co|Dispenser|
    US3731414A|1971-02-05|1973-05-08|B Murphy|Animal ear tags and applicators therefor|
    US3952438A|1971-07-06|1976-04-27|Herman Miller, Inc.|Animal marking apparatus|
    US3893813A|1973-10-26|1975-07-08|Humboldt Manufacturing Company|Laboratory clamp|
    IE42176B1|1974-11-19|1980-06-18|Dalton Rototag Ltd|Improvements in or relating to eartags|
    US4014748A|1975-12-22|1977-03-29|Marion Laboratories, Inc.|Anaerobic culture collecting and transporting apparatus|
    NZ180734A|1976-04-29|1980-02-21|Delta Plastics Ltd|Ear tag applicator retracting pin|
    FR2393586B1|1977-06-08|1980-12-05|Roussel Uclaf|
    AU533358B2|1978-12-18|1983-11-17|Allflex International Limited|Ear tags|
    US4359015A|1981-02-06|1982-11-16|Ritchey Eugene|Identification tag for livestock|
    US4425874A|1982-04-29|1984-01-17|Child Francis W|Dispenser|
    US4885855A|1982-09-29|1989-12-12|Fearing Manufacturing Co., Inc.|Antibacterial attachment|
    GB8519557D0|1985-08-03|1985-09-11|Sterimatic Holdings Ltd|Tag assemblies|
    US4694781A|1985-11-29|1987-09-22|Howe Steve R|Container for attachment to animal ear tags|
    US4878456A|1987-10-02|1989-11-07|An-Tech International Livestock Products|Animal tail tag for insecticide protection|
    NZ223074A|1987-12-23|1990-08-28|Magri Holland|Ear tag applicator, rotary magazine|
    US5005433A|1989-07-20|1991-04-09|Patton Eugene K|Asbestos sample removal tool|
    US5156160A|1990-06-22|1992-10-20|Bennett Lavon L|Adjustable biopsy device capable of controlling tissue sample size collected thereby|
    US5268148A|1990-12-18|1993-12-07|Saliva Diagnostic Systems, Inc.|Saliva sampling device and sample adequacy system|
    DE69217261T2|1991-03-08|1997-08-21|Shinsozai Sogo Kenkyusho Kk|Storage and mixing apparatus|
    US5482008A|1991-09-13|1996-01-09|Stafford; Rodney A.|Electronic animal identification system|
    US5189986A|1991-09-23|1993-03-02|Alza Corporation|Veterinary transdermal active agent delivery device|
    US5388588A|1993-05-04|1995-02-14|Nabai; Hossein|Biopsy wound closure device and method|
    US5526822A|1994-03-24|1996-06-18|Biopsys Medical, Inc.|Method and apparatus for automated biopsy and collection of soft tissue|
    US6126617A|1995-01-26|2000-10-03|Ascendia Ab|Impact-damped biopsy instrument|
    WO1996026675A1|1995-02-28|1996-09-06|Boston Scientific Corporation|Deflectable catheter for ablating cardiac tissue|
    US5902280A|1995-04-13|1999-05-11|Advanced Cytometrix, Inc.|Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith|
    FR2744702B1|1996-02-08|1998-03-20|Tebro|DEVICE FOR DISPENSING A FLUID PRODUCT CONTAINED IN A HERMETICALLY CLOSED TANK|
    US6070593A|1996-12-10|2000-06-06|Chase; Gene|Method and apparatus for cutting an end of a cigar|
    FR2758799B1|1997-01-24|1999-04-02|Stago Diagnostica|CLOSURE FOR REAGENT BOTTLE FOR USE BY AN ANALYZER|
    FR2768836B1|1997-06-11|2000-06-16|Reydet Finance|IDENTIFICATION DEVICE AND METHOD FOR MANUFACTURING THE ASSOCIATED DEVICE|
    DE19758633C2|1997-09-11|2003-10-23|Biopsytec Gmbh|Device for taking biological samples|
    JP2000146957A|1997-10-13|2000-05-26|Kikkoman Corp|Specimen extracting tool and instrument for smear test|
    US6509187B2|1998-05-25|2003-01-21|Agrobiogen Gmbh|Method and device for collection and preparation of tissue samples for molecular genetic diagnostics|
    US6145225A|1998-07-02|2000-11-14|Ritchey; Eugene B.|Animal ear tag assembly and component locking member|
    US6161034A|1999-02-02|2000-12-12|Senorx, Inc.|Methods and chemical preparations for time-limited marking of biopsy sites|
    US6080173A|1999-05-26|2000-06-27|Idx Medical Ltd.|Tissue punching instrument|
    GB2358061B|2000-01-09|2003-08-13|Sec Dep Of The Home Dept|Improvements in and relating to the collection and storage of samples|
    DE10026508A1|2000-05-24|2001-11-29|Kai Desinger|Surgical hollow tube|
    US6382827B1|2000-11-01|2002-05-07|Dade Behring Inc.|Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action|
    AU2094002A|2000-11-15|2002-05-27|Roy Caisley|System for tagging a biological object and for taking a sample of the biologicalobject|
    US20020066418A1|2000-12-05|2002-06-06|Fearing D. Michael|Combination visual and electronic animal identification tag|
    AT250852T|2001-01-01|2003-10-15|Agrobiogen Gmbh Biotechnologie|MODIFIED EAR BRANDS AND TISSUE COLLECTION METHOD|
    US20020118595A1|2001-02-26|2002-08-29|Miller Scott H.|Enclosed implantable material mixing system|
    DE10115790A1|2001-03-29|2002-10-17|Hauptner Und Richard Herberhol|Animal ear tag pliers|
    FR2823065B1|2001-04-04|2004-08-13|Chevillot Sa|EAR LABEL FOR MARKING ANIMALS WITH ORGANIC MATTER COLLECTION SYSTEM|
    NO314206B1|2001-04-30|2003-02-10|Erling Sundrehagen|Quantitative chemical analysis method, device / device, and application of said method and analysis set|
    FR2831389A1|2001-10-29|2003-05-02|Reyflex|Closure for animal ear tag has male and female connections with male section having cutting plug at end|
    US6984223B2|2001-11-13|2006-01-10|Becton, Dickinson And Company|Needle safety device|
    US6708432B2|2002-01-03|2004-03-23|Cardinal Industries, Inc.|Temper evident ear tag system|
    JP2005534943A|2002-07-30|2005-11-17|エージー−アイディーピーティーワイリミテッド|Sampling device|
    US7740597B2|2002-12-11|2010-06-22|Ethicon Endo-Surgery, Inc.|Biopsy device with sample tube|
    US20040167429A1|2003-02-20|2004-08-26|Roshdieh Babak B.|Cutaneous biopsy device with handle and disposable tips|
    WO2004082462A2|2003-03-17|2004-09-30|Tyco Healthcare Group, Lp|Endoscopic tissue removal apparatus and method|
    ITRN20030024A1|2003-08-08|2005-02-09|Genefast Srl|DEVICE FOR THE COLLECTION OF BIOLOGICAL AND / OR CHEMICAL SAMPLES.|
    US7107936B2|2003-09-04|2006-09-19|Mmi Genomics, Inc.|Device and method for animal tracking|
    WO2005072620A1|2004-01-16|2005-08-11|Andx, Inc.|Sample collection device and method|
    WO2005079441A2|2004-02-17|2005-09-01|Children's Hospital Medical Center|Injection device for administering a vaccine|
    US20050256425A1|2004-05-11|2005-11-17|Inpro Biotechnology, Inc.|Device, system and method for extracting and preparing brain tissue|
    EP1759638B1|2004-05-11|2009-04-08|Inrad, Inc.|Core biopsy device|
    NL1027712C1|2004-06-29|2005-12-30|Nehls Reinhard|System for marking a biological object and for taking a sample from the biological object.|
    JP2006026227A|2004-07-20|2006-02-02|Fujihira Industry Co Ltd|Method for obtaining piece of meat from animal|
    US20060021673A1|2004-07-27|2006-02-02|Stephan Rodewald|Self-sealing apparatus for chemical reaction vessel|
    BE1016247A5|2004-10-25|2006-06-06|Wijk Anton Van|IDENTIFICATION DEVICE AND METHOD FOR MANUFACTURING IT|
    US20070103314A1|2004-11-17|2007-05-10|Geissler Randolph K|Radio frequency animal tracking system|
    NZ541467A|2005-07-25|2008-01-31|Tagam Ltd|Punch tool for tissue sampling|
    US7854707B2|2005-08-05|2010-12-21|Devicor Medical Products, Inc.|Tissue sample revolver drum biopsy device|
    AR057801A1|2005-09-09|2007-12-19|Bayer Healthcare Llc|LABEL FOR ANIMAL EARS|
    EP1772104A2|2005-10-07|2007-04-11|Tsion Israel Medical Systems Ltd.|Contamination protection device and method for use|
    US20070142743A1|2005-12-16|2007-06-21|Provencher Kevin M|Tissue sample needle actuator system and apparatus and method of using same|
    US7871568B2|2006-01-23|2011-01-18|Quidel Corporation|Rapid test apparatus|
    US8038595B2|2006-01-25|2011-10-18|Beth Israel Deaconess Medical Center|Devices and methods for tissue transplant and regeneration|
    US7670299B2|2006-03-07|2010-03-02|Ethincon Endo-Surgery, Inc.|Device for minimally invasive internal tissue removal|
    WO2008003693A1|2006-07-04|2008-01-10|Tecan Trading Ag|Collecting device for biologically relevant samples|
    US20080227662A1|2006-09-08|2008-09-18|Jenrik Ag, Llc|Livestock tissue identification system|
    US20080064983A1|2006-09-08|2008-03-13|Jenrik Ag, Llc|Livestock tissue identification method and device|
    FR2906703B1|2006-10-06|2009-08-07|Affflex Europ Soc Par Actions|DEVICE FOR COLLECTING BIOLOGICAL TISSUE FOR ANIMAL IDENTIFICATION|
    EP1911347A1|2006-10-12|2008-04-16|Advance Design Ltd.|An ear marking arrangement and a method for ear marking a number of animals|
    EP2077757A4|2006-10-13|2010-02-17|Noble House Group Pty Ltd|Means for sampling animal blood|
    PL1920651T3|2006-11-08|2010-06-30|Reinhard Nehls|System for marking a non-human biological object and for taking a sample of the biological object|
    WO2008101497A1|2007-02-19|2008-08-28|Multi Biopsy Sampling Co. Aps|Biopsy forceps for taking one or more samples|
    JPWO2008152980A1|2007-06-12|2010-08-26|オリンパス株式会社|Container for mixing biological sample and reagent and method for mixing biological sample and reagent|
    FR2917574B1|2007-06-22|2010-05-07|Chevillot Sarl|AURICULAR MARKING BUCKLE WITH TISSUE FEEDING DEVICE|
    EP2050334B1|2007-10-18|2017-04-05|Allflex Europe SAS|An ear tag for marking an animal and for sampling tissue from said animal|
    WO2009076469A1|2007-12-11|2009-06-18|The University Of Medicine And Dentistry Of New Jersey|Amniopunch and uses thereof|
    FR2924899B1|2007-12-12|2012-03-02|Allflex Europe Sas|MARKING DEVICE FOR IDENTIFYING AND MARKING ANIMALS, AND MALE PART OF SUCH A DEVICE.|
    MX2010007058A|2008-01-07|2010-10-15|Eriginate Corp|Animal tag and method for making same.|
    DK176909B1|2008-06-12|2010-04-19|Ms2Solution Aps|Animal tagging device|
    AU2008249220B1|2008-11-26|2010-01-21|Allflex Europe|Animal identification tag and recycling process of such a tag|
    EP2374095A1|2008-12-06|2011-10-12|BR-Technic V/henrik Risbo Jeppesen|Radio frequency identification tag|
    FR2939281B1|2008-12-10|2014-07-04|Affflex Europ|DEVICE FOR SAMPLING AN ANIMAL TISSUE SAMPLE|
    FR2940011B1|2008-12-19|2014-11-28|Allflex Europe|DEVICE FOR TAKING ANIMAL TISSUE AND CORRESPONDING MEANS OF STORAGE|
    AT508708B1|2009-10-22|2011-06-15|Gerhard Bonecker|TEST SET FOR A PHOTOMETRIC MEASURING DEVICE AND PHOTOMETRIC MEASURING METHOD FOR A SAMPLE LIQUID|
    FR2961088B1|2010-06-09|2013-04-19|Allflex Europ|ANIMAL EQUIPMENT SAMPLING ASSEMBLY AND CORRESPONDING PACKAGING.|
    FR2961087B1|2010-06-09|2013-06-28|Allflex Europ|TOOL FOR SAMPLING AN ANIMAL TISSUE SAMPLE.|
    FR2963203B1|2010-07-30|2013-11-15|Allflex Europ|MARKING AND / OR ANIMAL TISSUE COLLECTION ASSEMBLY AND CORRESPONDING MARKING AND / OR LEANING TOOL.|
    FR2963536B1|2010-08-09|2014-02-28|Allflex Europ|ANIMAL IDENTIFICATION DEVICE AND CORRESPONDING MANUFACTURING DEVICE|
    FR2963722B1|2010-08-13|2012-08-10|Allflex Europ|ANIMAL IDENTIFICATION RESIN DEVICE AND METHOD FOR MANUFACTURING THE SAME|
    FR2978328B1|2011-07-28|2014-10-24|Allflex Europ|SYSTEM FOR SAMPLING AT LEAST ONE ANIMAL TISSUE SAMPLE, SAMPLE DEVICE, STORAGE DEVICE, AND MANUFACTURING METHOD THEREFOR.|
    US8985059B2|2012-09-24|2015-03-24|Y-Tex Corporation|Insecticide strip and combination with identification ear tag|US20070084897A1|2003-05-20|2007-04-19|Shelton Frederick E Iv|Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism|
    US9060770B2|2003-05-20|2015-06-23|Ethicon Endo-Surgery, Inc.|Robotically-driven surgical instrument with E-beam driver|
    US8215531B2|2004-07-28|2012-07-10|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument having a medical substance dispenser|
    US7669746B2|2005-08-31|2010-03-02|Ethicon Endo-Surgery, Inc.|Staple cartridges for forming staples having differing formed staple heights|
    US10159482B2|2005-08-31|2018-12-25|Ethicon Llc|Fastener cartridge assembly comprising a fixed anvil and different staple heights|
    US11246590B2|2005-08-31|2022-02-15|Cilag Gmbh International|Staple cartridge including staple drivers having different unfired heights|
    US9237891B2|2005-08-31|2016-01-19|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical stapling devices that produce formed staples having different lengths|
    US20070106317A1|2005-11-09|2007-05-10|Shelton Frederick E Iv|Hydraulically and electrically actuated articulation joints for surgical instruments|
    US7845537B2|2006-01-31|2010-12-07|Ethicon Endo-Surgery, Inc.|Surgical instrument having recording capabilities|
    US7753904B2|2006-01-31|2010-07-13|Ethicon Endo-Surgery, Inc.|Endoscopic surgical instrument with a handle that can articulate with respect to the shaft|
    US8820603B2|2006-01-31|2014-09-02|Ethicon Endo-Surgery, Inc.|Accessing data stored in a memory of a surgical instrument|
    US11207064B2|2011-05-27|2021-12-28|Cilag Gmbh International|Automated end effector component reloading system for use with a robotic system|
    US11224427B2|2006-01-31|2022-01-18|Cilag Gmbh International|Surgical stapling system including a console and retraction assembly|
    US20110295295A1|2006-01-31|2011-12-01|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical instrument having recording capabilities|
    US8186555B2|2006-01-31|2012-05-29|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting and fastening instrument with mechanical closure system|
    US8684253B2|2007-01-10|2014-04-01|Ethicon Endo-Surgery, Inc.|Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor|
    US8652120B2|2007-01-10|2014-02-18|Ethicon Endo-Surgery, Inc.|Surgical instrument with wireless communication between control unit and sensor transponders|
    US11039836B2|2007-01-11|2021-06-22|Cilag Gmbh International|Staple cartridge for use with a surgical stapling instrument|
    US7735703B2|2007-03-15|2010-06-15|Ethicon Endo-Surgery, Inc.|Re-loadable surgical stapling instrument|
    US8931682B2|2007-06-04|2015-01-13|Ethicon Endo-Surgery, Inc.|Robotically-controlled shaft based rotary drive systems for surgical instruments|
    US7753245B2|2007-06-22|2010-07-13|Ethicon Endo-Surgery, Inc.|Surgical stapling instruments|
    US7866527B2|2008-02-14|2011-01-11|Ethicon Endo-Surgery, Inc.|Surgical stapling apparatus with interlockable firing system|
    US7819298B2|2008-02-14|2010-10-26|Ethicon Endo-Surgery, Inc.|Surgical stapling apparatus with control features operable with one hand|
    US8636736B2|2008-02-14|2014-01-28|Ethicon Endo-Surgery, Inc.|Motorized surgical cutting and fastening instrument|
    US8758391B2|2008-02-14|2014-06-24|Ethicon Endo-Surgery, Inc.|Interchangeable tools for surgical instruments|
    JP5410110B2|2008-02-14|2014-02-05|エシコン・エンド−サージェリィ・インコーポレイテッド|Surgical cutting / fixing instrument with RF electrode|
    US8573465B2|2008-02-14|2013-11-05|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical end effector system with rotary actuated closure systems|
    US9179912B2|2008-02-14|2015-11-10|Ethicon Endo-Surgery, Inc.|Robotically-controlled motorized surgical cutting and fastening instrument|
    US9585657B2|2008-02-15|2017-03-07|Ethicon Endo-Surgery, Llc|Actuator for releasing a layer of material from a surgical end effector|
    US9386983B2|2008-09-23|2016-07-12|Ethicon Endo-Surgery, Llc|Robotically-controlled motorized surgical instrument|
    US8210411B2|2008-09-23|2012-07-03|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting instrument|
    US8608045B2|2008-10-10|2013-12-17|Ethicon Endo-Sugery, Inc.|Powered surgical cutting and stapling apparatus with manually retractable firing system|
    FR2940011B1|2008-12-19|2014-11-28|Allflex Europe|DEVICE FOR TAKING ANIMAL TISSUE AND CORRESPONDING MEANS OF STORAGE|
    US8517239B2|2009-02-05|2013-08-27|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument comprising a magnetic element driver|
    US20110024477A1|2009-02-06|2011-02-03|Hall Steven G|Driven Surgical Stapler Improvements|
    US8220688B2|2009-12-24|2012-07-17|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting instrument with electric actuator directional control assembly|
    FR2961087B1|2010-06-09|2013-06-28|Allflex Europ|TOOL FOR SAMPLING AN ANIMAL TISSUE SAMPLE.|
    FR2963203B1|2010-07-30|2013-11-15|Allflex Europ|MARKING AND / OR ANIMAL TISSUE COLLECTION ASSEMBLY AND CORRESPONDING MARKING AND / OR LEANING TOOL.|
    JP6224070B2|2012-03-28|2017-11-01|エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ．|Retainer assembly including tissue thickness compensator|
    US8777004B2|2010-09-30|2014-07-15|Ethicon Endo-Surgery, Inc.|Compressible staple cartridge comprising alignment members|
    US10945731B2|2010-09-30|2021-03-16|Ethicon Llc|Tissue thickness compensator comprising controlled release and expansion|
    US9629814B2|2010-09-30|2017-04-25|Ethicon Endo-Surgery, Llc|Tissue thickness compensator configured to redistribute compressive forces|
    US9861361B2|2010-09-30|2018-01-09|Ethicon Llc|Releasable tissue thickness compensator and fastener cartridge having the same|
    JP6305979B2|2012-03-28|2018-04-04|エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ．|Tissue thickness compensator with multiple layers|
    BR112013027794B1|2011-04-29|2020-12-15|Ethicon Endo-Surgery, Inc|CLAMP CARTRIDGE SET|
    US8695866B2|2010-10-01|2014-04-15|Ethicon Endo-Surgery, Inc.|Surgical instrument having a power control circuit|
    US9072535B2|2011-05-27|2015-07-07|Ethicon Endo-Surgery, Inc.|Surgical stapling instruments with rotatable staple deployment arrangements|
    MX350846B|2012-03-28|2017-09-22|Ethicon Endo Surgery Inc|Tissue thickness compensator comprising capsules defining a low pressure environment.|
    US9101358B2|2012-06-15|2015-08-11|Ethicon Endo-Surgery, Inc.|Articulatable surgical instrument comprising a firing drive|
    RU2636861C2|2012-06-28|2017-11-28|Этикон Эндо-Серджери, Инк.|Blocking of empty cassette with clips|
    US20140001231A1|2012-06-28|2014-01-02|Ethicon Endo-Surgery, Inc.|Firing system lockout arrangements for surgical instruments|
    US11197671B2|2012-06-28|2021-12-14|Cilag Gmbh International|Stapling assembly comprising a lockout|
    US9364230B2|2012-06-28|2016-06-14|Ethicon Endo-Surgery, Llc|Surgical stapling instruments with rotary joint assemblies|
    FR3001860B1|2013-02-12|2015-07-24|Allflex Europ|ANIMAL IDENTIFICATION SYSTEM COMPRISING A MALE PART, A FEMALE PART, AND A REMOVABLE DEVICE FOR STORING A SAMPLE.|
    US9517065B2|2013-02-28|2016-12-13|Ethicon Endo-Surgery, Llc|Integrated tissue positioning and jaw alignment features for surgical stapler|
    RU2669463C2|2013-03-01|2018-10-11|Этикон Эндо-Серджери, Инк.|Surgical instrument with soft stop|
    US9629629B2|2013-03-14|2017-04-25|Ethicon Endo-Surgey, LLC|Control systems for surgical instruments|
    US9687230B2|2013-03-14|2017-06-27|Ethicon Llc|Articulatable surgical instrument comprising a firing drive|
    US10136887B2|2013-04-16|2018-11-27|Ethicon Llc|Drive system decoupling arrangement for a surgical instrument|
    PL3004833T3|2013-06-05|2019-07-31|Snpshot Trustee Limited|Improvements in and relating to tissue sampling|
    US20150053746A1|2013-08-23|2015-02-26|Ethicon Endo-Surgery, Inc.|Torque optimization for surgical instruments|
    MX369362B|2013-08-23|2019-11-06|Ethicon Endo Surgery Llc|Firing member retraction devices for powered surgical instruments.|
    EP3057411A4|2013-10-18|2017-09-13|Snpshot Trustee Limited|A biopsy sampler, related parts and methods|
    US9962161B2|2014-02-12|2018-05-08|Ethicon Llc|Deliverable surgical instrument|
    US11259799B2|2014-03-26|2022-03-01|Cilag Gmbh International|Interface systems for use with surgical instruments|
    US10004497B2|2014-03-26|2018-06-26|Ethicon Llc|Interface systems for use with surgical instruments|
    JP6612256B2|2014-04-16|2019-11-27|エシコンエルエルシー|Fastener cartridge with non-uniform fastener|
    FR3024329B1|2014-07-31|2017-03-10|Allflex Europe|MALE PART OF ANIMAL IDENTIFICATION DEVICE, SAMPLE ORGAN, AND CORRESPONDING ANIMAL IDENTIFICATION SYSTEM.|
    KR20170035906A|2014-07-31|2017-03-31|알플렉스 유로프|Animal identification system comprising an animal identification device and a sampling member|
    BR112017004361A2|2014-09-05|2017-12-05|Ethicon Llc|medical overcurrent modular power supply|
    US9757128B2|2014-09-05|2017-09-12|Ethicon Llc|Multiple sensors with one sensor affecting a second sensor's output or interpretation|
    BR112017005981A2|2014-09-26|2017-12-19|Ethicon Llc|surgical staplers and ancillary materials|
    US10076325B2|2014-10-13|2018-09-18|Ethicon Llc|Surgical stapling apparatus comprising a tissue stop|
    US9924944B2|2014-10-16|2018-03-27|Ethicon Llc|Staple cartridge comprising an adjunct material|
    US11141153B2|2014-10-29|2021-10-12|Cilag Gmbh International|Staple cartridges comprising driver arrangements|
    US9844376B2|2014-11-06|2017-12-19|Ethicon Llc|Staple cartridge comprising a releasable adjunct material|
    US10736636B2|2014-12-10|2020-08-11|Ethicon Llc|Articulatable surgical instrument system|
    US9968355B2|2014-12-18|2018-05-15|Ethicon Llc|Surgical instruments with articulatable end effectors and improved firing beam support arrangements|
    US9987000B2|2014-12-18|2018-06-05|Ethicon Llc|Surgical instrument assembly comprising a flexible articulation system|
    US9844374B2|2014-12-18|2017-12-19|Ethicon Llc|Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member|
    US9844375B2|2014-12-18|2017-12-19|Ethicon Llc|Drive arrangements for articulatable surgical instruments|
    US10085748B2|2014-12-18|2018-10-02|Ethicon Llc|Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors|
    WO2016107825A1|2015-01-02|2016-07-07|Prionics Ag|Apparatus and methods for tissue sampling and identity-tag attachment|
    US11154301B2|2015-02-27|2021-10-26|Cilag Gmbh International|Modular stapling assembly|
    US9901342B2|2015-03-06|2018-02-27|Ethicon Endo-Surgery, Llc|Signal and power communication system positioned on a rotatable shaft|
    US9993248B2|2015-03-06|2018-06-12|Ethicon Endo-Surgery, Llc|Smart sensors with local signal processing|
    US10548504B2|2015-03-06|2020-02-04|Ethicon Llc|Overlaid multi sensor radio frequencyelectrode system to measure tissue compression|
    US10687806B2|2015-03-06|2020-06-23|Ethicon Llc|Adaptive tissue compression techniques to adjust closure rates for multiple tissue types|
    US10245033B2|2015-03-06|2019-04-02|Ethicon Llc|Surgical instrument comprising a lockable battery housing|
    US10617412B2|2015-03-06|2020-04-14|Ethicon Llc|System for detecting the mis-insertion of a staple cartridge into a surgical stapler|
    US11058425B2|2015-08-17|2021-07-13|Ethicon Llc|Implantable layers for a surgical instrument|
    US10238386B2|2015-09-23|2019-03-26|Ethicon Llc|Surgical stapler having motor control based on an electrical parameter related to a motor current|
    US10105139B2|2015-09-23|2018-10-23|Ethicon Llc|Surgical stapler having downstream current-based motor control|
    US10299878B2|2015-09-25|2019-05-28|Ethicon Llc|Implantable adjunct systems for determining adjunct skew|
    US10980539B2|2015-09-30|2021-04-20|Ethicon Llc|Implantable adjunct comprising bonded layers|
    US10285699B2|2015-09-30|2019-05-14|Ethicon Llc|Compressible adjunct|
    US10265068B2|2015-12-30|2019-04-23|Ethicon Llc|Surgical instruments with separable motors and motor control circuits|
    US10292704B2|2015-12-30|2019-05-21|Ethicon Llc|Mechanisms for compensating for battery pack failure in powered surgical instruments|
    US10368865B2|2015-12-30|2019-08-06|Ethicon Llc|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    US11213293B2|2016-02-09|2022-01-04|Cilag Gmbh International|Articulatable surgical instruments with single articulation link arrangements|
    US11224426B2|2016-02-12|2022-01-18|Cilag Gmbh International|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    MX2018010844A|2016-03-08|2019-01-10|Snpshot Trustee Ltd|Biological sampler, collector and storage container.|
    EP3426162A4|2016-03-08|2019-11-20|Snpshot Trustee Limited|Biological sampler, collector and storage container|
    WO2017153865A1|2016-03-08|2017-09-14|Snpshot Trustee Limited|Biological sampler, collector and storage container|
    US10966692B2|2016-03-08|2021-04-06|Snpshot Trustee Limited|Quick release driving tool|
    US10456137B2|2016-04-15|2019-10-29|Ethicon Llc|Staple formation detection mechanisms|
    US11179150B2|2016-04-15|2021-11-23|Cilag Gmbh International|Systems and methods for controlling a surgical stapling and cutting instrument|
    US10335145B2|2016-04-15|2019-07-02|Ethicon Llc|Modular surgical instrument with configurable operating mode|
    US10357247B2|2016-04-15|2019-07-23|Ethicon Llc|Surgical instrument with multiple program responses during a firing motion|
    US10368867B2|2016-04-18|2019-08-06|Ethicon Llc|Surgical instrument comprising a lockout|
    US11191539B2|2016-12-21|2021-12-07|Cilag Gmbh International|Shaft assembly comprising a manually-operable retraction system for use with a motorized surgical instrument system|
    US11160551B2|2016-12-21|2021-11-02|Cilag Gmbh International|Articulatable surgical stapling instruments|
    US20180168618A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Surgical stapling systems|
    US10779823B2|2016-12-21|2020-09-22|Ethicon Llc|Firing member pin angle|
    US20180168608A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Surgical instrument system comprising an end effector lockout and a firing assembly lockout|
    US10888322B2|2016-12-21|2021-01-12|Ethicon Llc|Surgical instrument comprising a cutting member|
    US11179155B2|2016-12-21|2021-11-23|Cilag Gmbh International|Anvil arrangements for surgical staplers|
    US20180168598A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Staple forming pocket arrangements comprising zoned forming surface grooves|
    US10675026B2|2016-12-21|2020-06-09|Ethicon Llc|Methods of stapling tissue|
    JP2020501779A|2016-12-21|2020-01-23|エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ|Surgical stapling system|
    US11134942B2|2016-12-21|2021-10-05|Cilag Gmbh International|Surgical stapling instruments and staple-forming anvils|
    US20180168633A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Surgical stapling instruments and staple-forming anvils|
    US20180168625A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Surgical stapling instruments with smart staple cartridges|
    US10307170B2|2017-06-20|2019-06-04|Ethicon Llc|Method for closed loop control of motor velocity of a surgical stapling and cutting instrument|
    US10646220B2|2017-06-20|2020-05-12|Ethicon Llc|Systems and methods for controlling displacement member velocity for a surgical instrument|
    US11090046B2|2017-06-20|2021-08-17|Cilag Gmbh International|Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument|
    US10881399B2|2017-06-20|2021-01-05|Ethicon Llc|Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument|
    US10980537B2|2017-06-20|2021-04-20|Ethicon Llc|Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations|
    US11071554B2|2017-06-20|2021-07-27|Cilag Gmbh International|Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements|
    USD890784S1|2017-06-20|2020-07-21|Ethicon Llc|Display panel with changeable graphical user interface|
    US10779820B2|2017-06-20|2020-09-22|Ethicon Llc|Systems and methods for controlling motor speed according to user input for a surgical instrument|
    US10888321B2|2017-06-20|2021-01-12|Ethicon Llc|Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument|
    US10993716B2|2017-06-27|2021-05-04|Ethicon Llc|Surgical anvil arrangements|
    US11141154B2|2017-06-27|2021-10-12|Cilag Gmbh International|Surgical end effectors and anvils|
    US10856869B2|2017-06-27|2020-12-08|Ethicon Llc|Surgical anvil arrangements|
    US11266405B2|2017-06-27|2022-03-08|Cilag Gmbh International|Surgical anvil manufacturing methods|
    US10903685B2|2017-06-28|2021-01-26|Ethicon Llc|Surgical shaft assemblies with slip ring assemblies forming capacitive channels|
    USD906355S1|2017-06-28|2020-12-29|Ethicon Llc|Display screen or portion thereof with a graphical user interface for a surgical instrument|
    US10765427B2|2017-06-28|2020-09-08|Ethicon Llc|Method for articulating a surgical instrument|
    US11259805B2|2017-06-28|2022-03-01|Cilag Gmbh International|Surgical instrument comprising firing member supports|
    US10639037B2|2017-06-28|2020-05-05|Ethicon Llc|Surgical instrument with axially movable closure member|
    US11246592B2|2017-06-28|2022-02-15|Cilag Gmbh International|Surgical instrument comprising an articulation system lockable to a frame|
    US20190000474A1|2017-06-28|2019-01-03|Ethicon Llc|Surgical instrument comprising selectively actuatable rotatable couplers|
    US10716614B2|2017-06-28|2020-07-21|Ethicon Llc|Surgical shaft assemblies with slip ring assemblies with increased contact pressure|
    US10932772B2|2017-06-29|2021-03-02|Ethicon Llc|Methods for closed loop velocity control for robotic surgical instrument|
    US11007022B2|2017-06-29|2021-05-18|Ethicon Llc|Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument|
    US10898183B2|2017-06-29|2021-01-26|Ethicon Llc|Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing|
    US9936676B1|2017-08-07|2018-04-10|Arrow Tag, LLC|Animal identification tag|
    US10058073B1|2017-08-07|2018-08-28|Arrow Tag, LLC|Animal tag attachment tool|
    JP1613222S|2017-09-08|2018-09-10|
    ZAA201800361S|2017-09-08|2019-01-30|Snpshot Trustee Ltd|Sampler devices|
    JP1614708S|2017-09-08|2018-10-01|
    US10743872B2|2017-09-29|2020-08-18|Ethicon Llc|System and methods for controlling a display of a surgical instrument|
    USD907648S1|2017-09-29|2021-01-12|Ethicon Llc|Display screen or portion thereof with animated graphical user interface|
    USD917500S1|2017-09-29|2021-04-27|Ethicon Llc|Display screen or portion thereof with graphical user interface|
    USD907647S1|2017-09-29|2021-01-12|Ethicon Llc|Display screen or portion thereof with animated graphical user interface|
    US10765429B2|2017-09-29|2020-09-08|Ethicon Llc|Systems and methods for providing alerts according to the operational state of a surgical instrument|
    US11134944B2|2017-10-30|2021-10-05|Cilag Gmbh International|Surgical stapler knife motion controls|
    US11090075B2|2017-10-30|2021-08-17|Cilag Gmbh International|Articulation features for surgical end effector|
    US10779903B2|2017-10-31|2020-09-22|Ethicon Llc|Positive shaft rotation lock activated by jaw closure|
    US10842490B2|2017-10-31|2020-11-24|Ethicon Llc|Cartridge body design with force reduction based on firing completion|
    US11071543B2|2017-12-15|2021-07-27|Cilag Gmbh International|Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges|
    US11033267B2|2017-12-15|2021-06-15|Ethicon Llc|Systems and methods of controlling a clamping member firing rate of a surgical instrument|
    US10869666B2|2017-12-15|2020-12-22|Ethicon Llc|Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument|
    US10779826B2|2017-12-15|2020-09-22|Ethicon Llc|Methods of operating surgical end effectors|
    US11197670B2|2017-12-15|2021-12-14|Cilag Gmbh International|Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed|
    US10743874B2|2017-12-15|2020-08-18|Ethicon Llc|Sealed adapters for use with electromechanical surgical instruments|
    US10828033B2|2017-12-15|2020-11-10|Ethicon Llc|Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto|
    US10779825B2|2017-12-15|2020-09-22|Ethicon Llc|Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments|
    US11006955B2|2017-12-15|2021-05-18|Ethicon Llc|End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments|
    US10687813B2|2017-12-15|2020-06-23|Ethicon Llc|Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments|
    US10966718B2|2017-12-15|2021-04-06|Ethicon Llc|Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments|
    US10743875B2|2017-12-15|2020-08-18|Ethicon Llc|Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member|
    US11045270B2|2017-12-19|2021-06-29|Cilag Gmbh International|Robotic attachment comprising exterior drive actuator|
    US10835330B2|2017-12-19|2020-11-17|Ethicon Llc|Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly|
    US10716565B2|2017-12-19|2020-07-21|Ethicon Llc|Surgical instruments with dual articulation drivers|
    US11020112B2|2017-12-19|2021-06-01|Ethicon Llc|Surgical tools configured for interchangeable use with different controller interfaces|
    US10729509B2|2017-12-19|2020-08-04|Ethicon Llc|Surgical instrument comprising closure and firing locking mechanism|
    USD910847S1|2017-12-19|2021-02-16|Ethicon Llc|Surgical instrument assembly|
    US11076853B2|2017-12-21|2021-08-03|Cilag Gmbh International|Systems and methods of displaying a knife position during transection for a surgical instrument|
    US11129680B2|2017-12-21|2021-09-28|Cilag Gmbh International|Surgical instrument comprising a projector|
    US10743868B2|2017-12-21|2020-08-18|Ethicon Llc|Surgical instrument comprising a pivotable distal head|
    US10779821B2|2018-08-20|2020-09-22|Ethicon Llc|Surgical stapler anvils with tissue stop features configured to avoid tissue pinch|
    US11207065B2|2018-08-20|2021-12-28|Cilag Gmbh International|Method for fabricating surgical stapler anvils|
    US10856870B2|2018-08-20|2020-12-08|Ethicon Llc|Switching arrangements for motor powered articulatable surgical instruments|
    US11083458B2|2018-08-20|2021-08-10|Cilag Gmbh International|Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions|
    US11045192B2|2018-08-20|2021-06-29|Cilag Gmbh International|Fabricating techniques for surgical stapler anvils|
    US10912559B2|2018-08-20|2021-02-09|Ethicon Llc|Reinforced deformable anvil tip for surgical stapler anvil|
    US10842492B2|2018-08-20|2020-11-24|Ethicon Llc|Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system|
    US11253256B2|2018-08-20|2022-02-22|Cilag Gmbh International|Articulatable motor powered surgical instruments with dedicated articulation motor arrangements|
    USD914878S1|2018-08-20|2021-03-30|Ethicon Llc|Surgical instrument anvil|
    US11039834B2|2018-08-20|2021-06-22|Cilag Gmbh International|Surgical stapler anvils with staple directing protrusions and tissue stability features|
    US11147553B2|2019-03-25|2021-10-19|Cilag Gmbh International|Firing drive arrangements for surgical systems|
    US11172929B2|2019-03-25|2021-11-16|Cilag Gmbh International|Articulation drive arrangements for surgical systems|
    US11147551B2|2019-03-25|2021-10-19|Cilag Gmbh International|Firing drive arrangements for surgical systems|
    US11253254B2|2019-04-30|2022-02-22|Cilag Gmbh International|Shaft rotation actuator on a surgical instrument|
    US11224497B2|2019-06-28|2022-01-18|Cilag Gmbh International|Surgical systems with multiple RFID tags|
    US11051807B2|2019-06-28|2021-07-06|Cilag Gmbh International|Packaging assembly including a particulate trap|
    US11246678B2|2019-06-28|2022-02-15|Cilag Gmbh International|Surgical stapling system having a frangible RFID tag|
    US11219455B2|2019-06-28|2022-01-11|Cilag Gmbh International|Surgical instrument including a lockout key|
    US11241235B2|2019-06-28|2022-02-08|Cilag Gmbh International|Method of using multiple RFID chips with a surgical assembly|
    US11259803B2|2019-06-28|2022-03-01|Cilag Gmbh International|Surgical stapling system having an information encryption protocol|
    US11234698B2|2019-12-19|2022-02-01|Cilag Gmbh International|Stapling system comprising a clamp lockout and a firing lockout|
    CN110940553A|2019-12-21|2020-03-31|中山大学附属第一医院|Femoral head cartilage sampler for electric experiment|
    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-09-03| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-03-24| B09A| Decision: intention to grant|
    2020-05-26| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1054563A|FR2961087B1|2010-06-09|2010-06-09|TOOL FOR SAMPLING AN ANIMAL TISSUE SAMPLE.|
    FR1054563|2010-06-09|
    PCT/EP2011/059636|WO2011154510A1|2010-06-09|2011-06-09|Tool for collecting a sample of animal tissue|
    [返回顶部]